Wednesday, July 31, 2019

Discuss the roles of language and reason in history Essay

The study of history is one in which people or communities attempt to understand the nature of humans through the study of events in the past. When we look at historiography or the writings of history, we are looking at the study of historical events that have been seen as relevant and meaningful by historians. So when we study this area of knowledge, we need to think about what affects the way we interpret it, and therefore by association, how it is taught to us. There are various components to the learning and teaching of history and perhaps the two most prominent components are language and reason; two ways of knowing. Language is fundamentally a systematic means of communicating by the use of sounds or conventional symbols. This is in itself linked to reason, which is a rational motive for a belief or action. Indeed language is a powerful tool that can communicate beliefs and facts but also manipulate such facts. Language has an effect on our emotions, our perception and what we believe in and can lead to history being manipulated over generations. Therefore, it is justifiable to say that this affects our reasoning. Therefore, I will be looking at how these ways of knowing affect the way in which a complex topic is taught: the Second World War (WW2) and some of its events. I will be addressing knowledge issues, which are questions that relate to our understanding of the world and us, combined with our desire for knowledge. I will look at how the holocaust is possibly taught in a German school, as well as how the Kamikaze attacks are taught in a Japanese school. I will also look at the way these events have been taught to me, as someone who attends a British school. The knowledge issues that will form the basis of my essay are: how do languages affect our opinion of a historical event, what role does our reasoning have in understanding historical events and whether we can study history without reason and language. I will be arguing that language and reason do have definitive roles in history. If we are to look at how WW2 may be taught in Germany, we have to perhaps look at Germany’s stance on the event now. Indeed a survey in Sarah Ann Gordon’s Book Hitler, Germans and ‘The Jewish Question’, showed the sentiments of the German people in the years after WW21. This can be seen below:  Statement  Percentage of people who agree  Hitler was right in his treatment of the Jews.  0%  Hitler went too far in his treatment of the Jews, but something had to be done to keep them in bounds. The actions against the Jews were in no way justified.  77%  Indeed, judging by the above results, it is possible that the majority of Germans abhor the Holocaust. The way in which they do so however, is very much linked into their language. Germany would most likely not want a repeat of the events of WW2 and so the way in which it is taught is one in which the actions of the Nazi party is abhorred, perhaps even more so than in the schools of other countries. Indeed if you look at the response of German historians and their analysis of WW2, many have been damning of events such as the holocaust. This can be seen with Hans-Ulrich Wehler, who in a 2006 interview expressed his support for the imprisonment of the British historian, David Irving, for Holocaust denial2.

Tuesday, July 30, 2019

A Pattern in The Least Successful Startup

A year ago I noticed a pattern in the least successful startups we'd funded: they all seemed hard to talk to. It felt as if there was some kind of wall between us. I could never quite tell if they understood what I was saying. This caught my attention because earlier we'd noticed a pattern among the most successful startups, and it seemed to hinge on a different quality. We found the startups that did best were the ones with the sort of founders about whom we'd say â€Å"they can take care of themselves.†The startups that do best are fire-and-forget in the sense that all you have to do is give them a lead, and they'll close it, whatever type of lead it is. When they're raising money, for example, you can do the initial intros knowing that if you wanted to you could stop thinking about it at that point. You won't have to babysit the round to make sure it happens. That type of founder is going to come back with the money; the only question is how much on what terms. It seemed od d that the outliers at the two ends of the spectrum could be detected by what appeared to be unrelated tests.You'd expect that if the founders at one end were distinguished by the presence of quality x, at the other end they'd be distinguished by lack of x. Was there some kind of inverse relation between resourcefulness and being hard to talk to? It turns out there is, and the key to the mystery is the old adage â€Å"a word to the wise is sufficient. † Because this phrase is not only overused, but overused in an indirect way (by prepending the subject to some advice), most people who've heard it don't know what it means.What it means is that if someone is wise, all you have to do is say one word to them, and they'll understand immediately. You don't have to explain in detail; they'll chase down all the implications. In much the same way that all you have to do is give the right sort of founder a one line intro to a VC, and he'll chase down the money. That's the connection. U nderstanding all the implications—even the inconvenient implications—of what someone tells you is a subset of resourcefulness. It's conversational resourcefulness.Like real world resourcefulness, conversational resourcefulness often means doing things you don't want to. Chasing down all the implications of what's said to you can sometimes lead to uncomfortable conclusions. The best word to describe the failure to do so is probably â€Å"denial,† though that seems a bit too narrow. A better way to describe the situation would be to say that the unsuccessful founders had the sort of conservatism that comes from weakness. They traversed idea space as gingerly as a very old person traverses the physical world. The unsuccessful founders weren't stupid.Intellectually they were as capable as the successful founders of following all the implications of what one said to them. They just weren't eager to. So being hard to talk to was not what was killing the unsuccessful s tartups. It was a sign of an underlying lack of resourcefulness. That's what was killing them. As well as failing to chase down the implications of what was said to them, the unsuccessful founders would also fail to chase down funding, and users, and sources of new ideas. But the most immediate evidence I had that something was amiss was that I couldn't talk to them.

Monday, July 29, 2019

Black Genocide Essay Example for Free

Black Genocide Essay Essay Topic: African American , Abortion â€Å"Black Genocide in the 21st century† also called â€Å"Maafa† is an anti-abortionist documentary made in 2009 that speaks about the relevance of birth control, White America and Black America, Planned Parenthood and how it was established, also, the conspiracy behind abortion. The movie also deeply discusses the argument between abortion being genocide and it specifically targeting African Americans. Black Genocide was a very intriguing and interesting piece of material that filled my knowledge with much more than I had intended it doing. Before watching this video, I knew a little about abortion but not about the black genocide part. You see, I knew that abortion was a way for the government to obtain legal rights to abort children who weren’t able to be cared for but I didn’t know the government was using abortion as a way to limit the black population. I also knew that African Americans were having a lot of abortions and there were, and still is a lot of abortion facilities but never put together the idea of how they were getting access to this information, furthermore, the connection between eugenics and genocide. During the film, I learned so much information that is disgusted me and changed many of my views toward abortion and other things. I learned that in the early 1800’s, Americans feared retribution and resurrection because slavery was supposed to have ended. Intermarriage also lead to the loss of international purity and for that, they had a plan of colonization. Colonization was an affect that took place, and caused African Americans to be sent back to Africa. After the colonization, the new philosophy was established and was called â€Å"eugenics†, the perfect solution to what was known as â€Å"negro dilemma.† I also learned that Eugenics believed that Africans were inferior and without guidance, they couldn’t make it. Margaret Sanger was the founder of the â€Å"American birth control league† and was successful for promoting abortion and birth control. After watching the 21st century of black genocide, I wanted to know more about the situation with the NAACP and why the government still hasn’t publicly announced the conflict between the protesters and there undercover targets. I’d also like to know more about the positive and negative eugenics and why White America was considered positive eugenics when it was used to try and dominate the black parts of America and used as a companion to exterminate African Americans. I’d also like to know more about Planned Parenthood and to see if the facilities were still being targeted in minority places. I’d also like to know more about White America and the Planned Parenthood meetings, and also if Planned Parenthood groups still targeted low poverty neighborhoods of different race, such as Caucasians. Black Genocide. (2016, Apr 12).

Sunday, July 28, 2019

Critically Analyse the Role of Customer Satisfaction and Loyalty in Essay

Critically Analyse the Role of Customer Satisfaction and Loyalty in the Strategic - Essay Example It is worth mentioning in this context that SMPP of a company comprises of certain specific steps on the basis of which companies should formulate as well as implement plans for accomplishing its objectives in an effective manner. These steps or procedures are required to be adopted by the management of companies with the objective of attaining a better strategic marketing plan inculcating the values of customer tastes and organisational profit objectives. There are usually four phases in an effective strategic marketing plan, which include determination of goals as well as objectives, analysing the situational position in various market segments, formulation of strategies and allocation of resources as well as monitoring process which should be followed in an appropriate manner with the aim of performing business activities effectively (Pajunen, 2012). Emphasising on this particular understanding, the paper will intend to discuss the SMPP strategies current practiced by companies to obtain high degree of customer satisfaction and loyalty. In this respect, the notions as well as perceptions of various authors will be interpreted through a rigorous literature review. Literature Review Strategic Marketing Planning Process (SMPP) The concept of SMPP is identified to be a vital element for companies to improve its competitive position in the global market segments (McDonald, 2006). As stated by McDonald (2006), SMPP is formulated as well as implemented by modern day organisations with the intention of acquiring better competitive advantages in relation to its products and/or services which are offered in the market segments. Companies should also identify their capabilities and business opportunities for conducting their business activities efficiently with the application of SMPP. McDonald (2006) stated that companies should determine market competitions as well as requirements of consumers in target market segments when focusing on SMPP implementation. Companies with the examination of all these factors will be able to perform their business operations effectively and competitively (McDonald, 2006). Moreover, McDonald (2006) also stated that there are certain advantages in accordance with which SMPP is adopt ed. For instance, with the virtues of effective SMPP implementations, companies will be able to identify opportunities as well as threats which are emerging in the worldwide market segments. Companies with the assistance of strategic plans will be able to adopt changes in the business environments in a rapid manner. Furthermore, companies will also be facilitated with the opportunity of allocating its resources in an appropriate manner with the implementation of an effective SMPP approach (McDonald, 2006). In a similar perspective, the article

Put the arguments for and against the idea that motivation (a Essay

Put the arguments for and against the idea that motivation (a learner's factor) plays a major part in second language acquisition) - Essay Example le new language acquiring process is something that we will delve into in detail and for this reason we find the exact basis as to how motivation plays its due part. There are a number of reasons that the students and different language learners offer when they are questioned as to why a new language would just be the order of the day for them. These responses include their willingness to have a sound and prosperous future that is full of growth and advancements. Also the reasons include their liking for a particular language and their incorporation of these languages into the countries in which they intend traveling or living in for a specified period of time. With the addition of more and more people wanting to learn a new language we see that the limited proficiency in English, the instructors are having a hard time making these people learn the new language. There is just so much that can be taught to these individuals. Enormous patience is required on their part as well as a huge amount of understanding and empathy. This is a mighty challenge for the teachers as they have to train the language seekers without having any prior training themselves. This would be done to promote second language development as well as to find out a little bit about the procedure of second language learning. [Favreau, M., & Segalowitz, 1983] The motivational aspects stem from the fact that the second language gives them a better understanding of the ways and means of the people who make use of the same in their day to day lives as well as the international usage of the new and acquired language. English is indeed the international language but learning Ger man, French, Spanish or Chinese on the part of the different language seekers/learners is a positive step and one that should surely be counted as a plus on their curriculum vitae. The focus therefore should not only be on young children but we can also take into consideration the older ones. As we are focusing on people from

Saturday, July 27, 2019

The causes of the civil war Essay Example | Topics and Well Written Essays - 2500 words

The causes of the civil war - Essay Example In the South, slavery was becoming an outdated method of agricultural production as industrialization was taking hold. Similar economies in the Caribbean, Latin America, and Europe had already abandon the practice of slavery and there was no reason to believe that the US would not soon follow. However, by 1860 events and policies enacted since the nations birth had moved the US to the brink of civil war. If slavery was not really at the heart of Americas motivation for going to war, then what were the reasons? The reasons why nations go to war are usually various and complicated, and the American Civil War is not an exception. Although the main reason which provoked the two sides in the Civil war was slavery, three different aspects of the impact of slavery were at the center of the disagreements. These aspects are political, economic, and social. Slavery was certainly a moral issue in regards to the Civil War and was always a contributing influence to the multiple causes of war. Since Americas inception its leaders, such as Thomas Jefferson, well understood that slavery must soon be abolished. In an 1805 letter to William Burwell, Jefferson wrote, "The value of the slave is every day lessening; his burden on his master daily increasing. Interest is therefore preparing the disposition to be just; and this will be goaded from time to time by the insurrectionary spirit of the slaves".1 However, the founding fathers failed to include slavery in the original documents. In addition, the Federation was designed as a weak federal government with significant states rights. States rights, a central issue of the Civil War, had been heavily debated since the Continental Congress. The Articles of Confederation, the first US Constitution, confirmed that the Federal government should be weak and the states should retain their individual po wer.2 The need to abolish slavery, and the weak federal system helped perpetuate the issue towards ultimate war. The conflicting goals

Friday, July 26, 2019

Geology of Puerto Rico Research Paper Example | Topics and Well Written Essays - 1750 words

Geology of Puerto Rico - Research Paper Example These rocks are overlain by younger  Oligocene  rocks to recent  carbonates. There are also othersedimentary rocks that are part and parcel of the geology of Puerto Rico. Typically, the Northern Oligocene to the rather recent carbonates is composed of Most of the caverns  and  karst  topography. The geology of Puerto Rico has made it very mountainous from the way the island was formed. There are also seventeen lakes in the island which are all manmade and fifty rivers (Otis, 2005). The island’s formation, topography, hydrography and climate make up Puerto Rico’s current geologic composition harmoniously; showcasing the natural beauty of the island. This paper seeks to analyze the geology of Puerto Rico from concepts of its formation, topography, hydrography and climate. Puerto Rico is strategically placed between the  Caribbean  and  North American plates, just at the boundary. As a result, there is deformation that is occurring to the island ion the present day due to the interactional stress between these plates. The results of these seismic events include geological hazards such as earthquakes, tsunamis and landslides. Looking into the structure of Puerto Rico, the Jurassic rocks are the oldest rocks (Meyerhoff, 1933). These rocks are mainly found at  Sierra Bermeja  in the southwest part of the island and are about 185 million years old. They are believed to have originated from the Pacific Ocean  realm and constitute the bulk of the oceanic crust. In the Jurassic period, the main body mass (the Pangaea super continent) was split into two. This led to the formation of two land masses. On the North was Laurasia and to the south was Gondwana. As a result, the continental climate was transformed from dry to humid due to the presence of more cost lines. This was the first process of the formation of Puerto Rico. The land masses were pushed from the ocean overlying on top of each other thus forming hilly and mountainous landscape. The

Thursday, July 25, 2019

LEGAL STUDIES Essay Example | Topics and Well Written Essays - 1500 words

LEGAL STUDIES - Essay Example ..†1 Therefore, it was his duty to preserve the information received by him by fax as secret. Being a civil servant, he must have had some experience in making difference between secret information and public one. Geoffrey might be found guilty under subsection 1, Section3 of the Act (1) as being â€Å"A person who is or has been a Crown servant or government contractor is guilty of an offence if without lawful authority he makes a damaging disclosure of—(a)any information, document or other article relating to international relations.† Geoffrey told his wife Jean about the information in the fax without lawful authority, as required by the law. According to Section 7 of the Act For the purposes of this Act, authorized disclosure is defined as â€Å"a disclosure by a Crown servant is made with lawful authority if, and only if, it is made in accordance with his official duty.† Geoffrey did not have the necessary authorization to disclose that kind of informa tion and therefore, he should have kept it to himself. On the other hand, Geoffrey might have not known that this information was secret, as the case description speaks about a secret agreement between Government ministers and the United Nations that no exact figures would be given as to the number involved. Therefore, he might raise the defence provided by the Official Secrets Act 1989, in Section 3, subsection (4), which stipulates that: â€Å"It is a defence for a person charged with an offence under this section to prove that at the time of the alleged offence he did not know, and had no reasonable cause to believe, that the information, document or article in question was such as is mentioned in subsection (1) above or that its disclosure would be damaging within the meaning of that subsection.† If Geoffrey can prove that he was not aware that the information was confidential and its disclosure would be damaging, he might avoid being held liable for disclosing it. On the other hand, by telling his wife, whom he, of course, knew that is a journalist, it must have occurred to his mind that his wife, as any journalist, might use that information in her own interest and make it public. I believe that Geoffrey, as a Crown servant, should have acted with caution as regards the information and find out if it is secret or not before passing it to other parties. His wife, on the other hand, might be held liable for publishing this information under Section 5 of the Act, within the provisions of which she might fall. Section 5 (2) stipulates that: â€Å"Subject to subsections (3) and (4) below, the person into whose possession the information, document or article has come is guilty of an offence if he discloses it without lawful authority knowing, or having reasonable cause to believe, that it is protected against disclosure by the foregoing provisions of this Act and that it has come into his possession as mentioned in subsection (1) above.† So, unle ss the disclosure was not damaging, Jean can be held liable under the Act. This is the case of the information passed to Jean by her husband, as he entrusted her that information, in accordance with Subsection 1, Section 5 of the Act. Geoffrey should have warned his wife about the importance of the information and the necessity to keep it secret. This is applicable, unless Geoffrey intentionally told his wife about t

Wednesday, July 24, 2019

(whatever you want) Essay Example | Topics and Well Written Essays - 500 words

(whatever you want) - Essay Example Because life will be less stressful, thanks to reduced traffic and a more pleasurable work environment, people will be much healthier when they reach retirement age than people in my parents’ generation. I will be able to stay active through most of my life, so when I don’t have to work at all anymore, I will still be in good shape to do things like wind surfing and skiing. Also, health will be improved if the country really turns to more green energy alternatives and the environment gets cleaned up. Less pollution in the air means we will have fewer cases of cancer and lung disease. People will be able to live much longer lives, particularly as medical knowledge and technology continues to be improved. In recent years, doctors have been taking a more holistic approach to medicine and this trend will probably continue so that a lot more will be known about human health by the time I retire. Since everyone will be living longer, either because they are able to stay healthier through most of their lives, because greater advances are made in medicine or because people won’t be as stressed out all the time, the demographic group will be very large. This may end up putting too much strain on the economy to try to maintain such a large population of retired people. For this reason, people like me who will probably be in better shape and still capable of working, might be expected to work much longer than the traditional retirement age of 65. This will probably be particularly true in fields like what I plan to go into, where work can be done from remote locations if necessary. Also, if the government decides to depend on nuclear power as a means of replacing fossil fuels, there will be a much greater chance that a dangerous accident might happen and make the atmosphere entirely toxic to people. Between that and the way that small and aggressive countries

Tuesday, July 23, 2019

Addressing Inequality Essay Example | Topics and Well Written Essays - 750 words

Addressing Inequality - Essay Example Being controversial issues, inequity and inequality are closely connected as inequity is the result of inequality. Inequality indicates the distribution of resources across society giving an idea of the difference between what rich and poor people can earn, average income, and redistribution of the county’s income. Countries characterized by high levels of inequality have high levels of poverty showing the fact that the distribution and redistribution of the country’s resources are linked to the poverty issues (Inequality: what is it?). One of the countries with high level of inequality is the U.S. The gap between poor and rich is the widest since 1929 and has doubled in 21 years. During the year (2001 and 2002) the number of poor rose by 1.7 million people. This imbalance is mostly caused by tax cuts which burden the poor more and more. There are complaints that the U.S. laws are unjust as they tolerate oppression of poor people and do not provide them minimum needs. I n Alabama, for example, people who get low income pay higher rate of income tax than those who are wealthy. As an example may be taken the timber industry that has the ownership for 71 percent of the land and pays only 2 percent of the tax. The paradox is that Americans are the richest nation but with the highest poverty rate (Lampman J.). Income inequality which is also among social issues of the U.S. is positively correlated with mental illness, low life expectancy, obesity, drug use, crime and teen pregnancy. Australia is also the country which has documented the growing gap between the poor and rich. The research shows that the most vulnerable Australians have been hardest hit by rising costs for health, education, and public transport services. Pensioners, unemployed, low-income people and aged have faced the harshest rising changes in the living costs. It has also been stated that essential services are placed beyond the reach of the above-mentioned section of the population. Education and medicine have become the services which are sometimes almost inaccessible to many people. The example may be education costs which soared 200 percent above the inflation rate and medical services which are 180 percent above the inflation rate (Holland K., Zimmer E). Inequality in Australia is present in various spheres of life, for example, the average female wage is only 65% of the average wage of a male, and racism is strongly expressed against aboriginals. Inequality is also a characteristic of the polarization of income groups into poor and rich. (Social Inequality in Australia) Hungary is among the countries with low economic growth, decline in wages, and high rate of inflation that has resulted from severe measures, introduces by the government, to make changes in health, educations, and to cut back on the deficit of the government. The above mentioned measures include co-payments in the sphere of health care, tuition at educational establishments. They were intr oduced in 2006 and caused social tension. Poverty of Hungarians is an extreme case of social inequalities. The number of poor is constantly growing. Vast job losses after 1990 caused rapid increase in inequalities and led to privatization and restructuring of wages and prices, and decline in the social transfers value. Declining income security has led to the number of health problems. Hungarians marry late, have few children and in most cases later in life. Life expectancy is also unsatisfactory as citizens live sorter than it would be expected taking into account economic development indicators. One more problem which results from inequality is high death rate especially among certain social groups of people. Hungary is the country for which such social problems

Greenwashing Case Essay Example for Free

Greenwashing Case Essay â…  .Introduction An appreciation for environmental protection has matured steadily in recent decades. With increasing concerns over the environment comes an increasing popularity of greenwashing. Consequently, companies whose actions do not match their environmentally-friendly promotions may mislead consumers in terms of the environmental benefits of a product or service. This essay explores possible reasons of the visible boom in greenwashing and claims that Nike, a sportswear and equipment supplier, deserves the accusation of greenwashing. â… ¡.Reasons for Greenwashing Clearly, the widespread popularity of greenwashing arises in the pursuance of reputation and sales. A recent survey conducted by Advertising Age indicates that 78% of customers prefer eco-friendly corporations to companies that are reckless with the environmental issue (Berkeley Media Studies Group 2008, p.2). The result of this survey serves as an incentive for companies to greenwash. Moreover, greenwashing definitely yields fruitful results for these companies. In a survey conducted by Landor Associates, BP, a corporation being accused of greenwashing, is considered to be more environmentally friendly than its counterparts, with its voters surpassing that of Shell by 6 per cent (Solman 2008, p.24). Most importantly, greenwashing helps BP promote sales from 2004($192 billion) to 2006($266 billion) (Solman 2008, p.24). With such a prime example of greenwashing, no wonder other companies follow in BPs footsteps. â… ¢.Nike’s official claims Nike claims that it regards environmental protection and humane management as part of their corporate responsibility. Primarily, several claims are made regarding environmental content of its products. Nike claims that T-shirts it sells in the US contain 3 per cent organic cotton and 90 per cent of its shoes are free from toxic glues, cleaners and solvents (Beder 2002, p.25). On top of that, it asserts that it eliminates the use of polyvinyl chloride (PVC) from its shoes (Beder 2002, p.27). Furthermore, it also advertises regarding good working conditions and happy workers in a Vietnamese factory (Beder 2002, p.25). â… £.Analysis of Claims It is doubtful whether Nike really produces clothes with 3 per cent organic cotton and 90 per cent of shoes are without toxic glues, cleaners and solvents. Rather than manufacturing its own products, Nike is only responsible for designing and marketing them and there is no supervision of the manufacturing process (Beder 2002, p.27). Furthermore, in order to promote credibility, Nike has the claim endorsed by United Nations. However, it turns out that United Nations do no monitoring of the claim made by Nike, either (Beder 2002, p.26). Consequently, Nike has no certification for this claim it makes. Therefore, there is no guarantee that the official claim regarding the environmental-friendly content in sportswear will be more than empty rhetoric. Due to the lack of valid evidence and certification, Nike’s claim considering the sportswear’s content commits the â€Å"sin of no proof† (TerraChoice 2007, p.8). Nike’s claim regarding PVC-free shoes may not be a true reflection of the fact. In a press conference, Soon after Nike’s repeated assurance regarding the PVC-free shoes, Greenpeace (a reliable organization against PVC) has claimed that Nike’s search for an alternative substitute for PVC have barely begun (Beder 2002, p.27). Given the fact that research has not lasted long, it is very unlikely that Nike is manufacturing shoes that are free from PVC, which makes this claim turn out to be a false claim. Nike commits the â€Å"sin of fibbing† (TerraChoice 2007, p.9) . Inconsistent with its advertisement, workers may not be so happy and contented in the Nike’s factory since Nike is definitely unkind to them. Nike is deceptive regarding comfortable working conditions. Specifically, in Vietnamese Nike plants, workers are exposed to carcinogens at 177 times safe levels and paid $10 for a 65-hour work per week (Beder 2002, p.27). Such differences between Nike’s claims and its behaviors are called bluewashing, which is categorized as one kind of greenwashing. Bluewashing refers to corporations that wrap themselves in the flag of human rights and labor rights, while their actions are quite otherwise (Corpwatch 2001, p.2). Furthermore, there is no uniform definition of happiness. Not only does the company misuse workers, it also makes a vague commitment because happiness is a feeling that varies from person to person. Such ambiguity proves that Nike commits the â€Å"sin of vagueness† (TerraChoice 2007, p.9). â… ¤.Counter-Arguments While Nike fails to realize certain official claims, it improves the environment and sustainability. Specifically, Nike claims that materials used in shoeboxes are 100% recycled and these shoeboxes weigh 10% less than those made up of non-recyclable paper (Stoner 2006, p.4). Nike helps alleviate deforestation by using recycled materials, thereby contributing to sustainable development and environmental protection. On the other hand, while Nike spends $1.13 billion on advertising and promoting the reputation of its products in 2003, it only donates $100,000 since 1998 to education programs for Nike workers. Compared with charity, it seems that much more funds are invested in advertising. The endeavor to greenwash far outweighs the effort to assume social responsibility. Hence, Nike is still greenwashing. â… ¥.Conclusion Overall, this paper reports that there are some reasons for companies to greenwash and even though Nike makes some effort to protect the environment, it has every reason to be accused of greenwashing. The reasons for most companies whose actions do not conform to their environmentally-friendly claims are simple: the pursuits of profits and goodwill. Despite Nike’s contribution towards environmental conservation and sustainability, several official claims regarding working conditions of employees and raw materials of products lack of evidence and clarity. Owing to the proliferation of greenwashing, customers should consider the environmental impact rather than advertising and packaging when shopping. â… ¦.References Beder S, 2002, ‘Putting the Boot In’, The Ecologist, April, pp. 24-28. Berkeley Media Studies Group, 2008, ‘Food Marketers Greenwash Junk Food’, Adweek, March, pp.1-3 CorpWatch, 2001, ‘Greenwash Fact Sheet’, CorpWatch, pp.1-2 Solman G, 2008, ‘Coloring Public Opinion?’, Adweek. January.14, pp22-24 Stoner C, 2006, ‘Corporate Greenings: Nike’, Peakinsight, pp. 1-13 TerraChoice Environmental Marketing Inc. 2007, ‘The Six Sins of Greenwashing’, November, pp.1-12

Monday, July 22, 2019

CanGo Analysis Essay Example for Free

CanGo Analysis Essay 1. CanGo has too many activities without having specific goals or setting priorities. As they find something that needs to be accomplished, it is always as soon as possible without setting definite time deadlines. Setting priorities is one way to insure that the tasks which need immediate attention are worked on first, while other task can be delayed because they are not as important. Being able to schedule people to complete specific task requires careful planning while know what resources are available. According to the Business Dictionary, a resource is â€Å"an economic or productive factor required to accomplish an activity† (Resource, 2013). CanGo needs to make a chart showing what its resources are which includes how much time each employee is able to work, how much money they can spend or invest, and what needs to be done by when. This can be accomplished in a number of different methods depending on the personnel who will be responsible for compiling the data. As shown on the Adaptive Path website, one method would be to use a spreadsheet which shows three major criteria and then apply a scale to them graphing the results. Equally important, once the priorities are determined, is setting specific deadlines for completion of task so that the employees know exactly when a report is needed, or when another department needs a specific resource if a resources needs to be shared or allocated, such as an employee working on multiple tasks. When setting the times, it is also important to know if one task needs to be completed before another on starts or if tasks can be worked on by different employees concurrently.  Setting up a written schedule or calendar, for example in Microsoft Outlook which everyone can view would be a good tool so each employee knows who is working on what and when it needs to be done. 2. CanGo needs to find out their customer base so that they can market to current customers and bring in new customers. There are a few ways to find their customer base. This first step to help find a customer base is to make the company a brand name. They need to make the company known to everyone for the great services and products offered. This will make the company more noticeable on any search engine or social media. Another step to finding the base would be to use onsite analytics. Google is the best known option for this. This will analyze the sites traffic patterns. It shows what websites they come from, how long they stay on your site and each individual page. This can even determine what page the customers get to and then leave (Staff Editor). If there is a certain page that customers’ get to and then leave the site, than this is the page that needs to be looked over and re-done. CanGo should also take advantage of social media. If CanGo used a social media outlet such as Facebook, their fans could leave comments and say what they like and dislike about the company. This can help fix any problems within the company. The final step in reaching a good customer base is to make sure their website is user friendly. Make sure the homepage has the most important content on it and that it has easy to understand menus for the customers to navigate. The company should also make sure to look at the reviews both good and bad and leave all of them on there. By showing that you are not trying to hide anything the customers will have more respect for the company. . CanGo wants to implement a new technology that involves a new layout that incorporates barcoding and automated storage and retrieval systems (ASRS). Jack is proposing this new implementation by contrasting the new technology versus CanGo’s current technology. Jack assures Juan that every cost has been included in the detailed analysis, but when Juan asks about how they are going to deal with the IT department, Jack replies that they need to make sure that the entire department is focus about 70 % of their time to this project in multiple locations. He also remarks that the department has to be pulled off from their current projects, so this implementation can be a priority. Prior to make the final decision of purchasing ASRS technology, there needs to be some deeper discussion as to what would happen to the security of the company’s network if the IT department had to spend more time on data integration. According to Ehow website, â€Å"the information technology department in an organization is responsible for the architecture, hardware, software and networking of computers† meaning that putting the IT department full time on the implementation of ASRS technology, can cause improper function of the mainly IT department functions, for instance, server maintenance (Kelchner, n. d. ). Agreeing to Wisegeek website statement, â€Å"if maintenance is not conducted on a computer network, regardless of whether the network is small or large, pplication software usually will not run as well as expected. In some cases, a network may even experience total or partial network failure if proper maintenance is not conducted. † Jack’s proposal can cause CanGo extra costs that have not been accountable for and put the entire company’s network at risk (server maintenance, n. d. ). In other to make this analysis effective, Jack should meet up with the IT department first and discuss how the implementation of this new technology will impact IT’s current work schedule. Jack and the IT department need to come with a plan that includes a work schedule for the new implementation without interrupting current projects. Therefore, if extra hours are demanded to complete the implementation whether CanGo will pay overtime to the IT department employees or temporary IT employees will be hired, this cost has to be added to the analysis. When choosing a strategy, every single department that is involved in the implementation should be contacted and informed about the project prior to present the final analysis.  It seems that Jack didn’t contact or discuss the implementation of ASRS technology with the IT department. 4. CanGo consumer buying process is in question when one of CanGo’s employee shares an elevated statistic that reveals over 75% of online shoppers don’t end up buying the products that they have selected in the website; as a result, Andrew replies that CanGo’s website mirrors the consumers choice by applying product recognition, informative search, alternating evaluation, etc. It seems that CanGo does not have an ongoing method for tracking hits vs. purchases on their website. The problem is that CanGo is not evaluating their consumer buying process properly. Andrew clearly wonders if that high statistic applies to CanGo clients. According to Aspire website, â€Å"using website metrics and tracking your leads and conversions should play a vital role in measuring what’s working and what’s not on your company’s website. Building up a history of metrics will enable you to identify trends and opportunities, analyze your traffic data to consistently improve your site’s effectiveness, and monitor your lead generation process, conversion rates, and your return on investment. CanGo should invest in website metrics because this will allow CanGo to conduct proper follow up that will confirm if the implemented consumer buying process is satisfactory (Website metrics, n. d. ). 5. CanGo needs to monitor the changes in purchases so that they can modify their marketing strategy. There are a few ways that CanGo can monitor changes. The company should start using web bugs on their site. A web bug is a graphic in a website or a graphic-enabled e-mail message. The Web bug can confirm when the message or page is viewed and record the IP address of the viewer (Privacy Rights Clearinghouse). This can help determine how many people are viewing their homepage and any other page on their site. CanGo can also apply direct marketing to their site. Direct marketing is a sales pitch targeted to a person based on prior consumer choices (Privacy Rights Clearinghouse). An example would be if the customer buys a romantic novel, then there will be suggestions for other romantic novels in a similar nature. Another method CanGo can use is behavioral marketing. Behavioral Marketing is the practice of collecting and compiling a record of individuals online activities, interests, preferences, and/or communications over time. Companies engaged in behavioral targeting routinely monitor individuals, the searches they make, the pages they visit, the content they view, their interactions on social networking sites, and the products and services they purchase (Privacy Rights Clearinghouse). After they have done the tracking they are able to show advertisements to the customers based on their behavior. This type of marketing is used through cookies, flash cookies, device fingerprinting and many other technologies. Whenever the customer goes to websites or social media that have advertisements on the side, the company’s ad would be there if the services were something that interested the customer. 6. CanGo seems to lack knowledge of unfamiliar territory. Since the online entertainment market is becoming saturated with entrepreneurs entering the industry, CanGo can definitely benefit from researching this particular market before they enter it. There are many reasons for any company that’s entering a new market to research it first. One reason is because it’s a way of keeping up with market trends, and in today’s fast paced world it’s paramount to stay on top of the industry and business trends. Lacking knowledge of unfamiliar territory can be extremely costly to an organization. Expanding into a new market involves a great deal of market research in addition to target customers. CanGo needs to develop an in-depth understanding of market growth rates, forecasted demand, competitors, and potential barriers to entry. CanGo isn’t entering a relatively undefined market, however, its new territory for the company. Needless to say maintaining a competitive edge is an important aspect of management today because organizations exist in a more global environment than in the past. Within most industries organizations compete with other companies that are able to provide the same goods and services. According to Steve Jobs, â€Å"Some people say, ‘give the customers what they want. ’ But that’s not my approach. Our job is to figure out what they’re going to want before they do. I think Henry Ford once said, ‘if I’d asked customers what they wanted, they would have told me, ‘A faster horse! ’’ People don’t know what they want until you show it to them. That’s why I never rely on market research. Our task is to read things that are not yet on the page. † This was a pretty controversial quote but it was how he actually felt. Unfortunately, although he was extremely successful and considered a genius by many there we’re times in his career where understanding customers’ wants could have led to even more success, such as with his computing company NeXT. There are both and cons to researching a market before entering but the pros definitely outweigh the cons. researching your market is also very vital to understanding your target market and increasing sales. There are many reasons for CanGo to conduct research on a market they’re entering, for instance, identifying potential customers. It’s important who will be using your product or service. Are they male or female? How old they are? and so on. It’s also important to understand CanGo’s existing customers such as; why would customers choose their product over their competition. A market should be prioritized based on the strategic fit and the ability for CanGo to serve them. CanGo should be able to answer questions like: Are there gaps in this marketplace that can be filled? If so can they do better than their competitors? What value can they deliver to this market and how much are they willing to pay for it? (Isaacson, 2011).

Sunday, July 21, 2019

Rituximab Discovery Process

Rituximab Discovery Process Description of the Target Disease Rituximab (Rituxan) is a distinct monoclonal antibody for curing of non-Hodgkin’s lymphoma(NHL) or chronic lymphocytic leukemia. This drug is also used in conjunction with methotrexate to cure symptoms of rheumatoid arthritis. This form of cancer begins from the lymphatic system and extends all over the body. In this disease, tumor grows from lymphocytes-a variety of white blood cell. The lymphatic system is a fraction of the immune system and aids battle infections and other ailments in addition to sieving out bacteria. Clear liquid called lymph runs via the lymphatic vessels and have white blood cells called lymphocytes that fight infections (Kim 266). Although there are several diverse kinds of lymphoma that exist, this specific type is mostly widespread. The major indicator of the health is the presence of a bump in a lymph node. In the UK, over 11,000 infections of lymphoma are detected each year. Non-Hodgkin’s lymphoma is related with ageing as the chances of gett ing the illness increases with age and its typical age of detection is estimated at 65. While the root of the health condition is unidentified, the risk features of developing it consist of having a health condition that deteriorates the immune system, previous contact with high amounts of radiation and being formerly in contact with Epstein-Barr virus. The standard way to verify the presence of this form of lymphoma is by conducting a biopsy (investigation of infected lymph bump. Survival chances of a patient with illness differ significantly depending on the actual type, status and phase of the lymphoma. Rituximab (Rituxan) vaccine is used in the curing of lymphoma and was discerned at IDEC Pharmaceuticals’ laboratories in 1991 and marketed by Genentech, a subordinate of Roche Group. The antibody was hereditarily engineered and used to generate high-yield expression structures. The US Food and Drug Administration (FDA) endorsed Rituximab in 1997 for curing this type of lymphoma. The vaccine received EU endorsement in June 1998 and sold under the brand name MabThera. On January 2011, the FDA endorsed Rituxan for treatment of superior follicular lymphoma (Carson et al. 820). Pharmaceutical Discovery Process of Rituxan As a curative IgG1 kappa antibody, Rituxan has mouse variable areas separated from anti-CD20 antibody. The antibody targets the lymphoma by binding itself with high resemblance to the cells having the CD20 antigen present on the exterior of normal B cells, excluding other regular cells. It mediates complement-reliant tissue lysis in the existence of human balance and antibody-reliant cellular cytotoxicity. The vaccine helps the immune system of the body to eradicate the stained CD20 B cells, reproduce new strong tissues from the lymphoid and takes them back to normal phases within a period of twelve months. In addition, the drug has been proven to stimulate apoptosis and modifies chemo-resistant lymphoma cells into in vitro (Ghetie et al. 1395). Clinical Phases of Rituximab Clinical trials are potential biomedical studies on human beings that are created to gather information about precise question on biomedical interventions. They are vital to the development of new drugs and vaccines used to prevent and cure diseases. Clinical researches are carried out to ascertain whether an innovative medication is secure and effective. Such studies are conducted after satisfactory information has been collected and approved by health authorities in the country of research. Ideally, clinical trials on new medicines comprises of four stages. Each phase of the procedure is regarded as a distinct clinical trial and the medicine development goes through all the stages over several years. After successfully proceeding through all the four phases, the drug is eventually endorsed by the regulatory authority for utilization in the whole population. The first phase of clinical development of Rituximab began in 1993. This phase involves the examination of biochemical effects of medicines on the body (pharmacodynamics) and the assessment of the body affects a drug (pharmacokinetics). In single-arm (pharmacodynamics) research, 166 patients who had B cell lymphoma were given four doses of 375 m/m2 of Rituxan as an intravenous infusion on weekly basis. Patients who had tumor of more than10cm in the marginal blood were not included in the study. It was observed that the infusion of Rituxan caused reduction of circulating B cells. Among the 166 patients infected with lymphoma, circulating B cells were lessened in the initial three weeks with continued reduction for 6 months following the treatment, in 83% of the patients. B cell revival began at about six months and the mean B cell levels went back to usual levels by 12 months after conclusion of treatment. It was also observed that there were continued and statistically considerable d epletion in serum levels from five to eleven months, after Rituximab administration Idusogie (Esohe et al. 1480). In pharmacokinetics study, 203 lymphoma patients were given four doses of 375mg/m2 Rituxan intravenous infusion on weekly basis. Rituxan was identified in the patients’ serum within 3 to 6 months following conclusion of treatment. The pharmacokinetic outline of Rituximab when given in form of six infusions of 375mg/m2in conjunction with six doses of chemotherapy was comparable to that observed with Rituximab only. In accordance to 298 non-Hodgkin’s patients who were given Rituximab dose once weekly, scrutiny of information indicated that the median terminal eradication lifespan was twenty two days (series of 6 to 52 days). The patients who had more CD19 cell tally or bigger measurable tumor before treatment indicated higher clearance. Age and sex had no impact on the Rituximab’s pharmacokinetics (Byrd et al. 790). Patients were exposed to varying from a single mixture up to a period of two years. Rituxan was researched in single and regulated trials. Majority of the patients obtained 375mg/m2 of Rituxan infusion, provided as a solitary agent on weekly basis up to eight doses, in conjunction with eight doses of chemotherapy or 16 doses of chemotherapy. Many of the lymphoma patients reported various infusion reactions comprising of fever, nausea, angioedema, headache, rash, vomiting, pruritus, myaldia, bronchospasm and dizziness after the initial Rituxan infusion. The infusion responses generally happened in 30 to 120 minutes after the initial infusion and steadied with slowing of the Rituxan infusion coupled with helpful care. The occurrence of the infusion effects was highest at the in initial infusion (77%) and reduced gradually with each preceding infusion. Patients who previously had untreated health condition and did not show a rank 3 or 4 reaction associated with infusion in cycle 1 and obtained of 90 minutes Rituxan infusion at cycle 2, the occurrence of Grade3 to 4 infusion associated responses was 1.1% on or a day following the infusion. In cycles 2 to 8, the occurrence of Grade 3 to 4 infusion responses after the 90 minutes was 2.8% on or a day following the infusion (McLaughlin et al. 1765). Severe infections (Grade 3 or 4), consisting of sepsis, happened in not more than 5% of the lymphoma patients in the single-arm researches. The general occurrence of illnesses was 31% (viral 10%, unknown 6%, bacterial 19% and fungal 1%). In the haphazard regulated researches where Rituxan had been given after chemotherapy for the healing of the medical condition, non-Hodgkin’s lymphoma, the speed of infection was greater amongst the patients who had been given Rituxan. In scattered lymphoma patients with large B-cell, viral infections happened more repeatedly for those who had obtained Rituxan. For lymphoma patients who had been given Rituximab monotheraphy, 48% of them displayed cytopenias of score 3 and 4. These comprised lymphopenia (40%), thrombocytopenia (2%). leucopenia (4%) and neutropenia (6%) .The mean period was 14 days for lymphopenia (range, 1 to 588 days) and 13 days for neutropenia (range, 2 to 116 days). Further, a single incidence of red cell aplastic (transient anemia) and two incidences of hemolytic anemia after Rituxan treatment happened at some stages in the single-arm researches. In the researches of monotheraphy, induced B-cell reduction happened in 71% to 81% of the lymphoma patients. Reduced serum levels of IgM and IgG happened in 14% of the patients (Idusogie et al. 1487). In phase III of the clinical trials were based on primary Rituxan and maintenance. This clinical trial was carried out in an open and randomized way comprising of two treatment stages and 1217 non-Hodgkin’s patients were enrolled. The research assessed the safety of Rituxan when mixed with chemotherapy in curing patients possessed with the medical condition. The principal outcome gauge was to unearth the Progression Free Survival (PFS) duration from randomization to development, death or relapse. The secondary result measure consisted assessment of response paces, chemotherapy treatments mixed both with and devoid of Rituxan and event motivated endurance endpoints. For the initial treatment, eight doses of Rituxan mixed with diverse chemotherapy were utilized. Patients who reacted to the first treatment were dispersed to obtain Rituxan on one occasion in a period of two months, for duration of two years, as the only agent. The resulted obtained indicated that the prescription of Rituxan in conjunction with chemotherapy for the particular period multiplied twice the PFS in the lymphoma patients. The research also confirmed that the protection and effectiveness of 375mg/m2 Rituxan was constant in the subsequently utilized pivotal researches when utilized solely or in conjunction with chemotherapy unlike those who ceased receiving Rituxan. Patients who were given Rituxan showed Grade 2 infection. Grade 3 to 4 severe responses of small white blood cell tally and infections were reported to be advance in Rituxan group. Post Marketing Experience As these reactions are detailed willingly from a populace of tentative size, it is impossible to dependably approximate their frequency or develop an informal association to drug exposure. Choices to consider in these reactions when labeling are normally based on the following aspect: seriousness of response, incidence of reporting, or potency of causal attachment to Rituxan. There are no sufficient and well-regulated researches on the use of Rituximab in expectant. post marketing information pointed out that B lymphocytopenia cell typically enduring not more than six months can happen in infants subjected to Rituximab in the uterus. Rituximab was discovered in the serum of newborns after birth. NHL is a severe illness that necessitates treatment. Rituximab ought to be utilized only during pregnancy if the probable gain to the mother validates potential threat to the fetus. Reproduction researches in cynomolgus monkeys at motherly exposures comparable to human curative exposures indi cated no sign of teratogenic effects. Although B cell tissue was lessened in the progeny of treated monkeys, b cell tally returned to usual points after six months of delivery (Leget et al. 547). In the case of nursing mothers, it is unidentified whether Rituxan is produced into human milk. Published information proposes that antibodies present in breast milk stops from going into the infant circulations in significant amounts. FDA has not necessitated pediatric researches in Polyarticular Juvenile Idiopathic Arthritis (PJIA) people of ages below 16 years due to worry of potential extended immune suppression in the growing immature immune system. Therefore, the safety of Rituxan in people with pediatric condition has not been ascertained. Immunogenicity Just like with all curative proteins, there is a possibility of immunogenicity. The indentified occurrence of positivity of antibody in an assay is greatly reliant on various factors comprising assay sensitivity, sample handling, assay methodology, concomitant treatments, sample gathering timing and underlying ailment. Due to the above reasons, assessment of the occurrence of antibodies to Rituximab and to other results may be deceiving. While utilizing an ELISA assay, Human Anti-Chimerical Antibody (HACA) was observed in (1.1%) 4 of 436 people with the lymphoma acquiring sole-agent Rituxan. 75% of the patients had purposive clinical reaction (Leget et al. 549). After the successful completion of the clinical trials on November 26, 1997, the Food and Drug Administration endorsed Rituximab, for showing the presence of follicular lymphoma. It formed the foremost monoclonal antibody endorsed for curing of cancer and the foremost sole agent endorsed precisely for healing of the specific lymphoma. Rituximab in conjunction with chemotherapy (CHOP) is better to CHOP only in the curing of huge lymphoma cells and various forms of B-cell lymphomas. The appropriate intravenous dose of 375mg/m2 is four weekly infusions. Healing is endured and outpatient treatment is feasible. Severe incidences are mainly grade 1 and 2, happening mostly with the initial infusion. In phase II sole-agent, the overall reaction pace was 50% with 10 months mean time to progression in patients. The bigger multicenter clinical test of 166 patients, the general reaction tempo was 48% (6% complete and 42% incomplete reactions). The median duration of reaction was 11 months and 13 months for responders. Activity has also been observed in patients with huge disease. Rituximab, endorsed for curing cancer, is safe and valuable in treating people with the health condition (Jazirehi Benjamin 2120). Mechanism of Action Rituximab attaches itself particularly to the antigen CD20, (B-lymphocyte-restricted segregation antigen, Bp35), a transmembrane protein that has a molecular mass of about 35 kD centered on B-lymphocytes. In the particular lymphoma, the antigen is shown on 90% of the B cells. However, the antigen does not exist on hematopoietic cells, normal plasma tissues or pro-B cells. CD20 controls an initial stride in the activation procedure for tissue cycle initiation and segregation, and probably operates as a calcium ion path.CD20 is not eradicated from the cell exterior and is not internalized when the antibody starts binding. B cells function also in the pathogenesis of the disease, rheumatoid arthritis and are related to chronic synovitis. In this situation, B cells might be operating at multiple locations in the autoimmune process, going through generation of rheumatoid factor (RF), antigen presentation and other autoantibodies production. The Fab realm of Rituximab attaches to the antig en CD20 present on the disease and its domain enlists immune effectors roles to intervene B-cell into vitro. Probable means of cell lysis comprise of Antibody-Dependent Cell Mediated cytotoxicity (ADCC) and Complement-Dependent Cytotoxitiy (CDC) (Janas et al. 442). The antibody has been demonstrated to stimulate apoptosis in the B-cell lymphoma. During tissue cross-reactivity, it was noted that Rituximab attached on the lymphoid tissues in the thymus, and on greater part of B-lymphocytes in marginal lymph and blood lumps. Little binding was seen in the non-lymphoid cells examined. Rituxan Prescription Administration of Rituxan to patients can cause severe side effects, which can eventually lead to death. Infusion reactions are the major usual side effects that occur. Severe infusion responses normally happen within 24 hours of initial infusion. It is important for patients to receive medicines to aid in reducing the possibility of having adverse infusion reactions from doctors. Patients with adverse infusion reaction history and other severe infections must notify their physicians before obtaining Rituxan. In case of occurrence of symptoms such as rash, sudden cough, itchiness, weakness and palpitations, patients should contact their doctors to obtain medication immediately. Other adverse side effects encompass Hepatitis B Virus reactivation, severe skin reaction and Progressive Multifocal Leukoencephalopathy (PML). Rituxan is administered by intravenous infusion through a needle. Blood tests are normally performed to ensure that no conditions that can safe hinder use of Rituxan ( Grillo-Là ³pez Antonio 770). The success and effectiveness of Rituximab has resulted in the development of advance anti-CD20 monoclonal antibodies. The advance value of Rituximab has given it superior edge over other drugs available in the market for the healing of the lymphoma. Amid its enhanced binding effect to cancerous B cells, Rituximab continues to dominate the market. Works cited Byrd, John C., et al. Rituximab therapy in hematologic malignancy patients with circulating blood tumor cells: association with increased infusion-related side effects and rapid blood tumor clearance. Journal of Clinical Oncology 17.3 (1999): 791-791. Carson, Kenneth R., et al. Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project. The lancet oncology 10.8 (2009): 816-824. Ghetie, M. A., Bright, H., Vitetta, E. S. (2001). Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood, 97(5), 1392-1398. Grillo-Là ³pez, Antonio J. Rituximab (Rituxan ®/MabThera ®): the first decade (1993-2003). Expert review of anticancer therapy 3.6 (2003): 767-779. Janas, E., et al. Rituxan (antià ¢Ã¢â€š ¬Ã‚ CD20 antibody)à ¢Ã¢â€š ¬Ã‚ induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis. Clinical Experimental Immunology 139.3 (2005): 439-446. Jazirehi, Ali R., and Benjamin Bonavida. Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkins lymphoma: implications in chemosensitization and therapeutic intervention. Oncogene 24.13 (2005): 2121-2143. Kim, Julian A. Targeted therapies for the treatment of cancer. The American journal of surgery 186.3 (2003): 264-268. Leget, Gail A., and Myron S. Czuczman. Use of rituximab, the new FDA-approved antibody. Current opinion in oncology 10.6 (1998): 548-551. McLaughlin, Peter, et al. Clinical status and optimal use of rituximab for B-cell lymphomas. Oncology (Williston Park, NY) 12.12 (1998): 1763-9. Idusogie, Esohe E., et al. Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc. The Journal of Immunology 164.8 (2000): 4178-4184. Rapoport, A. P., et al. Autotransplantation for advanced lymphoma and Hodgkins disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy. Bone marrow transplantation 29.4 (2002): 303-312.

Saturday, July 20, 2019

Essay examples --

1. MOTIVATION AND JOB SATISFACTION: The process that accounts for an individual's intensity, direction and persistence of effort toward attaining a goal o Intensity – how hard a person tries o Direction – effort that is channeled toward, and o consistent with, organizational goals o Persistence – how long a person can maintain effort Motivation is the driving force within individuals that impels them to action and job satisfaction is having a positive feeling about one's job resulting from an evaluation of its characteristics. There are a lot of motivation theories like Maslow's need hierarchy which consists of five levels of needs which drives human to work, motivates them and gives them satisfaction according to the achievements. 1. Psychological needs: These are the basic needs that is food clothing and shelter for which the person works. After these needs get fulfilled the person looks up the next level to achieve the needs of next level. 2. Safety Needs: These are the needs after the first level of needs get satisfied. These include the job security, regular income, etc. After these needs get fulfilled the person looks up the next level to achieve the needs of next level. 3. Social Needs: After the basic psychological needs and the safety needs are met the person now looks for the social needs which is social belongingness at the place of work. The person need to be socially accepted in the organization. After these needs get fulfilled the person looks up the next level to achieve the needs of next level. 4. Self Esteem Needs: These needs are related to the rewards and recognition that the employee looks for in the organization. The person wants to be rewarded and recognized on the work and the efforts that he has put in com... ...ation they will be cheerful always, will have smile on their face then only they can make their customers happy, respectful states when they are actually knowing how to respect their elders when they come in any organisation and last but not the least is that they should be needy should be knowing the importance of the money. The recommendations under this can be that since the workers who are hired should be well aware of what’s going on in any organisation. Also when after recruitment when the employee is working efficiently he should be recommended further for promotion, this will go a long way in any organisation. REFRENCING- http://www.scribd.com/doc/100858948/17/Subjective-Factor-Theory http://www.scribd.com/doc/100858948/17/Subjective-Factor-Theory http://www.ukessays.com/essays/management/theories-of-leadership-in-tata-group-management-essay.php

Global Warming Essay -- Environment Climate Change

Global Warming and The Environment Global warming is a term used to describe a gradual increase in the average temperature of the Earth's atmosphere and its oceans (All About Global Warming, 2007, para.1). There is no doubt this is an important matter that will impact planet earth for many years to come. Global warming is a critical issue that impacts the entire world and the potential consequences caused by it will have a negative impact if human contribution is not reduced. Although many people disagree with the causes and outcomes, there is certainly enough information available to support the argument. At this time, global warming is said to be a crisis with carbon and emissions of Co2 being made out to be the culprit (Turpin, 2007, p.30). These are just two of the multiple human contributions that add to the cause. The relationship between human effect and the significant impact on the environment are in relation with the respect to global warming. It is not necessarily the human need or desire to drive gas guzzling vehicles, littering the earth, or to cut down precious trees to destroy the environment, but the need of those on earth to be wasteful and destructive. Another factor to consider in the contribution is that livestock are also responsible for 18% of green house gas (methane and nitrous oxide) world wide ? more then all the planes, trains and automobiles on the planet (Turpin, 2007, p30). In addition to the natural causes of global warming, humans also play a significant part in the contribution. Although little can be done to reverse the damage that is already apparent, there are many habits that can be changed by those living on this earth to slow down the process, outside of the natural causes. Some o... ...007). All About Global Warming. Retrieved April 11, 2008, from http://www.livescience.com/globalwarming/ NASA Top Story. (2003). Recent Warming of Arctic May Affect Worldwide Climate. Retrieved April 12, 2008, from http://www.nasa.gov/centers/goddard/news/topstory/2003/1023esuice.html. New York Times.(2008). Global Warming. Retrieved April 12, 2008, from http://topics.nytimes.com/top/news/science/topics/globalwarming/index.html?inline=nyt-classifier# Species Extinctions. (2007). Species Extinctions still rising, experts warn. Retrieved April 11, 2008, from http://www.msnbc.msn.msn.com/id/20738173/ Turpin, J. (2007). Is Carbon the Culprit? Air conditioning Heating & Refridgeration. Retrieved April 11,2008, from http://wf2dnvr3.webfeat.org/fvVkJ13/url=http://web.ebscohost.com/ehost/pdf?vid=5&hid=16&sid=ac7d44ab-7544-4b7c-9bda-9eafea0d9398%40sessionmgr107

Friday, July 19, 2019

Character Sketch of Ethan Frome Essay -- Essays Papers

Character Sketch of Ethan Frome â€Å"Guess he’s been in Starkfield too many winters. Most of the smart ones get away† (6). That, said by Harmon Gow, was definitely how Ethan Frome could be described. Too many winters in Starkfield had taken its toll on Ethan, and it was obvious to see. Ethan, â€Å"the ruin of a man† (3), just hadn’t gotten out of Starkfield in time. Now, as the narrator related, â€Å"There was something bleak and unapproachable in his face; and he was so stiffened and grizzled I took him for an old man† (4). Ethan had clearly become a depressed individual and had been for a very long time. Ethan was very sad man. Ethan never got to finish his studies and thought about it from time to time. Even at the beginning of the book when the narrator dropped his copy of Popular Science, it was obvious Ethan had a sad, nostalgic tone about him as he talked about the fact that he used to study in that field. Ethan was also sad that he had to come home every night to a woman who didn’t love him. Zeena was a self-absorbed woman whose only happiness came from other’s grief. The moment she left town every minute of Ethan’s life became better. The thought of Zeena even made him jump as shown in this quotation: â€Å"Ethan, a moment earlier, had felt himself on the brink of eloquence; but the mention of Zeena had paralyzed him† (84). Ethan was also sad because he couldn’t run away with Mattie and live in another place with her. This is extremely evident in this quotation: â€Å" A moment...

Thursday, July 18, 2019

Part Three Chapter VI

VI Things denied, things untold, things hidden and disguised. The muddy River Orr gushed over the wreckage of the stolen computer, thrown from the old stone bridge at midnight. Simon limped to work on his fractured toe and told everyone that he had slipped on the garden path. Ruth pressed ice to her bruises and concealed them inexpertly with an old tube of foundation; Andrew's lip scabbed over, like Dane Tully's, and Paul had another nosebleed on the bus and had to go straight to the nurse on arrival at school. Shirley Mollison, who had been shopping in Yarvil, did not answer Ruth's repeated telephone calls until late afternoon, by which time Ruth's sons had arrived home from school. Andrew listened to the one-sided conversation from the stairs outside the sitting room. He knew that Ruth was trying to take care of the problem before Simon came home, because Simon was more than capable of seizing the receiver from her and shouting and swearing at her friend. ‘†¦ just silly lies,' she was saying brightly, ‘but we'd be very grateful if you could remove it, Shirley.' He scowled and the cut on his fat lip threatened to burst open again. He hated hearing his mother asking the woman for a favour. In that moment he was irrationally annoyed that the post had not been taken down already; then he remembered that he had written it, that he had caused everything: his mother's battered face, his own cut lip and the atmosphere of dread that pervaded the house at the prospect of Simon's return. ‘I do understand you've got a lot of things on †¦' Ruth was saying cravenly, ‘but you can see how this might do Simon damage, if people believe †¦' ‘Yes.' Ruth sounded tired. ‘She's going to take those things about Dad off the site so, hopefully, that'll be the end of it.' Andrew knew his mother to be intelligent, and much handier around the house than his ham-fisted father. She was capable of earning her own living. ‘Why didn't she take the post down straight away, if you're friends?' he asked, following her into the kitchen. For the first time in his life, his pity for Ruth was mingled with a feeling of frustration that amounted to anger. ‘She's been busy,' snapped Ruth. One of her eyes was bloodshot from Simon's punch. ‘Did you tell her she could be in trouble for leaving defamatory stuff on there, if she moderates the boards? We did that stuff in comput – ‘ ‘I've told you, she's taking it down, Andrew,' said Ruth angrily. She was not frightened of showing temper to her sons. Was it because they did not hit her, or for some other reason? Andrew knew that her face must ache as badly as his own. ‘So who d'you reckon wrote that stuff about Dad?' he asked her recklessly. She turned a face of fury upon him. ‘I don't know,' she said, ‘but whoever they are, it was a despicable, cowardly thing to do. Everyone's got something they'd like to hide. How would it be if Dad put some of the things he knows about other people on the internet? But he wouldn't do it.' ‘That'd be against his moral code, would it?' said Andrew. ‘You don't know your father as well as you think you do!' shouted Ruth with tears in her eyes. ‘Get out – go and do your homework – I don't care – just get out!' Yet the deletion of the post could not remove it from the consciousness of those who were passionately interested in the forthcoming contest for Barry's seat. Parminder Jawanda had copied the message about Simon Price onto her computer, and kept opening it, subjecting each sentence to the scrutiny of a forensic scientist examining fibres on a corpse, searching for traces of Howard Mollison's literary DNA. He would have done all he could to disguise his distinctive phraseology, but she was sure that she recognized his pomposity in ‘Mr Price is certainly no stranger to keeping down costs', and in ‘the benefit of his many useful contacts'. ‘Minda, you don't know Simon Price,' said Tessa Wall. She and Colin were having supper with the Jawandas in the Old Vicarage kitchen, and Parminder had started on the subject of the post almost the moment they had crossed the threshold. ‘He's a very unpleasant man and he could have upset any number of people. I honestly don't think it's Howard Mollison. I can't see him doing anything so obvious.' ‘Don't kid yourself, Tessa,' said Parminder. ‘Howard will do anything to make sure Miles is elected. You watch. He'll go for Colin next.' Tessa saw Colin's knuckles whiten on his fork handle, and wished that Parminder would think before she spoke. She, of anyone, knew what Colin was like; she prescribed his Prozac. Vikram was sitting at the end of the table in silence. His beautiful face fell naturally into a slightly sardonic smile. Tessa had always been intimidated by the surgeon, as she was by all very good-looking men. Although Parminder was one of Tessa's best friends, she barely knew Vikram, who worked long hours and involved himself much less in Pagford matters than his wife. ‘I told you about the agenda, didn't I?' Parminder rattled on. ‘For the next meeting? He's proposing a motion on the Fields, for us to pass to the Yarvil committee doing the boundary review, and a resolution on forcing the drug clinic out of their building. He's trying to rush it all through, while Barry's seat's empty.' She kept leaving the table to fetch things, opening more cupboard doors than was necessary, distracted and unfocused. Twice she forgot why she had got up, and sat down again, empty-handed. Vikram watched her, everywhere she moved, from beneath his thick eyelashes. ‘I rang Howard last night,' Parminder said, ‘and I told him we ought to wait until we're back up to the full complement of councillors before we vote on such big issues. He laughed; he says we can't wait. Yarvil wants to hear our views, he said, with the boundary review coming up. What he's really scared of is that Colin's going to win Barry's seat, because it won't be so easy to foist it all on us then. I've emailed everyone I think will vote with us, to see if they can't put pressure on him to delay the votes, for one meeting †¦ ‘†The Ghost of Barry Fairbrother†,' Parminder added breathlessly. ‘The bastard. He's not using Barry's death to beat him. Not if I can help it.' Tessa thought she saw Vikram's lips twitch. Old Pagford, led by Howard Mollison, generally forgave Vikram the crimes that it could not forget in his wife: brownness, cleverness and affluence (all of which, to Shirley Mollison's nostrils, had the whiff of a gloat). It was, Tessa thought, grossly unfair: Parminder worked hard at every aspect of her Pagford life: school ftes and sponsored bakes, the local surgery and the Parish Council, and her reward was implacable dislike from the Pagford old guard; Vikram, who rarely joined or participated in anything, was fawned upon, flattered and spoken of with proprietary approval. ‘Mollison's a megalomaniac,' Parminder said, pushing food nervously around her plate. ‘A bully and a megalomaniac.' Vikram laid down his knife and fork and sat back in his chair. ‘So why,' he asked, ‘is he happy being chair of the Parish Council? Why hasn't he tried to get on the District Council?' ‘Because he thinks that Pagford is the epicentre of the universe,' snapped Parminder. ‘You don't understand: he wouldn't swap being chair of Pagford Parish Council for being Prime Minister. Anyway, he doesn't need to be on the council in Yarvil; he's already got Aubrey Fawley there, pushing through the big agenda. All revved up for the boundary review. They're working together.' Parminder felt Barry's absence like a ghost at the table. He would have explained it all to Vikram and made him laugh in the process; Barry had been a superb mimic of Howard's speech patterns, of his rolling, waddling walk, of his sudden gastrointestinal interruptions. ‘I keep telling her, she's letting herself get too stressed,' Vikram told Tessa, who was appalled to find herself blushing slightly, with his dark eyes upon her. ‘You know about this stupid complaint – the old woman with emphysema?' ‘Yes, Tessa knows. Everyone knows. Do we have to discuss it at the dinner table?' snapped Parminder, and she jumped to her feet and began clearing the plates. Tessa tried to help, but Parminder told her crossly to stay where she was. Vikram gave Tessa a small smile of solidarity that made her stomach flutter. She could not help remembering, as Parminder clattered around the table, that Vikram and Parminder had had an arranged marriage. (‘It's only an introduction through the family,' Parminder had told her, in the early days of their friendship, defensive and annoyed at something she had seen in Tessa's face. ‘Nobody makes you marry, you know.' But she had spoken, at other times, of the immense pressure from her mother to take a husband. ‘All Sikh parents want their kids married. It's an obsession,' Parminder said bitterly.) Colin saw his plate snatched away without regret. The nausea churning in his stomach was even worse than when he and Tessa had arrived. He might have been encased in a thick glass bubble, so separate did he feel from his three dining companions. It was a sensation with which he was only too familiar, that of walking in a giant sphere of worry, enclosed by it, watching his own terrors roll by, obscuring the outside world. Tessa was no help: she was being deliberately cool and unsympathetic about his campaign for Barry's seat. The whole point of this supper was so that Colin could consult Parminder on the little leaflets he had produced, advertising his candidacy. Tessa was refusing to get involved, blocking discussion of the fear that was slowly engulfing him. She was refusing him an outlet. Trying to emulate her coolness, pretending that he was not, after all, caving under self-imposed pressure, he had not told her about the telephone call from the Yarvil and District Gazette that he had received at school that day. The journalist on the end of the line had wanted to talk about Krystal Weedon. Had he touched her? Colin had told the woman that the school could not possibly discuss a pupil and that Krystal must be approached through her parents. ‘I've already talked to Krystal,' said the voice on the end of the line. ‘I only wanted to get your – ‘ But he had put the receiver down, and terror had blotted out everything. Why did they want to talk about Krystal? Why had they called him? Had he done something? Had he touched her? Had she complained? The psychologist had taught him not to try and confirm or disprove the content of such thoughts. He was supposed to acknowledge their existence, then carry on as normal, but it was like trying not to scratch the worst itch you had ever known. The public unveiling of Simon Price's dirty secrets on the council website had stunned him: the terror of exposure, which had dominated so much of Colin's life, now wore a face, its features those of an ageing cherub, with a demonic brain seething beneath a deerstalker on tight grey curls, behind bulging inquisitive eyes. He kept remembering Barry's tales of the delicatessen owner's formidable strategic brain, and of the intricate web of alliances that bound the sixteen members of Pagford Parish Council. Colin had often imagined how he would find out that the game was up: a guarded article in the paper; faces turned away from him when he entered Mollison and Lowe's; the headmistress calling him into her office for a quiet word. He had visualized his downfall a thousand times: his shame exposed and hung around his neck like a leper's bell, so that no concealment would be possible, ever again. He would be sacked. He might end up in prison. ‘Colin,' Tessa prompted quietly; Vikram was offering him wine. She knew what was going on inside that big domed forehead; not the specifics, but the theme of his anxiety had been constant for years. She knew that Colin could not help it; it was the way he was made. Many years before, she had read, and recognized as true, the words of W. B. Yeats: ‘A pity beyond all telling is hid at the heart of love.' She had smiled over the poem, and stroked the page, because she had known both that she loved Colin, and that compassion formed a huge part of her love. Sometimes, though, her patience wore thin. Sometimes she wanted a little concern and reassurance too. Colin had erupted into a predictable panic when she had told him that she had received a firm diagnosis of Type 2 diabetes, but once she had convinced him that she was not in imminent danger of dying, she had been taken aback by how quickly he dropped the subject, how completely he reimmersed himself in his election plans. (That morning, at breakfast, she had tested her blood sugar with the glucometer for the first time, then taken out the prefilled needle and inserted it into her own belly. It had hurt much more than when deft Parminder did it. Fats had seized his cereal bowl and swung round in his chair away from her, sloshing milk over the table, the sleeve of his school shirt and onto the kitchen floor. Colin had let out an inchoate shout of annoyance as Fats spat his mouthful of cornflakes back into his bowl, and demanded of his mother, ‘Have you got to do that at the bloody table?' ‘Don't be so damn rude and disgusting!' shouted Colin. ‘Sit up properly! Wipe up that mess! How dare you speak to your mother like that? Apologize!' Tessa withdrew the needle too fast; she had made herself bleed. ‘I'm sorry that you shooting up at breakfast makes me want to puke, Tess,' said Fats from under the table, where he was wiping the floor with a bit of kitchen roll. ‘Your mother isn't â€Å"shooting up†, she's got a medical condition!' shouted Colin. ‘And don't call her â€Å"Tess†!' ‘I know you don't like needles, Stu,' said Tessa, but her eyes were stinging; she had hurt herself, and felt shaken and angry with both of them, feelings that were still with her this evening.) Tessa wondered why Parminder did not appreciate Vikram's concern. Colin never noticed when she was stressed. Perhaps, Tessa thought angrily, there's something in this arranged marriage business †¦ my mother certainly wouldn't have chosen Colin for me †¦ Parminder was shoving bowls of cut fruit across the table for pudding. Tessa wondered a little resentfully what she would have offered a guest who was not diabetic, and comforted herself with the thought of a bar of chocolate lying at home in the fridge. Parminder, who had talked five times as much as anybody else all through supper, had started ranting about her daughter, Sukhvinder. She had already told Tessa on the telephone about the girl's betrayal; she went through it all again at the table. ‘Waitressing with Howard Mollison. I don't, I really don't know what she's thinking. But Vikram – ‘ ‘They don't think, Minda,' Colin proclaimed, breaking his long silence. ‘That's teenagers. They don't care. They're all the same.' ‘Colin, what rubbish,' snapped Tessa. ‘They aren't all the same at all. We'd be delighted if Stu went and got himself a Saturday job – not that there's the remotest chance of that.' ‘ – but Vikram doesn't mind,' Parminder pressed on, ignoring the interruption. ‘He can't see anything wrong with it, can you?' Vikram answered easily: ‘It's work experience. She probably won't make university; there's no shame in it. It's not for everyone. I can see Jolly married early, quite happy.' ‘Waitressing †¦' ‘Well, they can't all be academic, can they?' ‘No, she certainly isn't academic,' said Parminder, who was almost quivering with anger and tension. ‘Her marks are absolutely atrocious – no aspiration, no ambition – waitressing – â€Å"let's face it, I'm not going to get into uni† – no, you certainly won't, with that attitude – with Howard Mollison †¦ oh, he must have absolutely loved it – my daughter going cap in hand for a job. What was she thinking – what was she thinking?' ‘You wouldn't like it if Stu took a job with someone like Mollison,' Colin told Tessa. ‘I wouldn't care,' said Tessa. ‘I'd be thrilled he was showing any kind of work ethic. As far as I can tell, all he seems to care about is computer games and – ‘ But Colin did not know that Stuart smoked; she broke off, and Colin said, ‘Actually, this would be exactly the kind of thing Stuart would do. Insinuate himself with somebody he knew we didn't like, to get at us. He'd love that.' ‘For goodness sake, Colin, Sukhvinder isn't trying to get at Minda,' said Tessa. ‘So you think I'm being unreasonable?' Parminder shot at Tessa. ‘No, no,' said Tessa, appalled at how quickly they had been sucked into the family row. ‘I'm just saying, there aren't many places for kids to work in Pagford, are there?' ‘And why does she need to work at all?' said Parminder, raising her hands in a gesture of furious exasperation. ‘Don't we give her enough money?' ‘Money you earn yourself is always different, you know that,' said Tessa. Tessa's chair faced a wall that was covered in photographs of the Jawanda children. She had sat here often, and had counted how many appearances each child made: Jaswant, eighteen; Rajpal, nineteen; and Sukhvinder, nine. There was only one photograph on the wall celebrating Sukhvinder's individual achievements: the picture of the Winterdown rowing team on the day that they had beaten St Anne's. Barry had given all the parents an enlarged copy of this picture, in which Sukhvinder and Krystal Weedon were in the middle of the line of eight, with their arms around each other's shoulders, beaming and jumping up and down so that they were both slightly blurred. Barry, she thought, would have helped Parminder see things the right way. He had been a bridge between mother and daughter, both of whom had adored him. Not for the first time, Tessa wondered how much difference it made that she had not given birth to her son. Did she find it easier to accept him as a separate individual than if he had been made from her flesh and blood? Her glucose-heavy, tainted blood †¦ Fats had recently stopped calling her ‘Mum'. She had to pretend not to care, because it made Colin so angry; but every time Fats said ‘Tessa' it was like a needle jab to her heart. The four of them finished their cold fruit in silence.

Wednesday, July 17, 2019

My Fashion, My Self, My Life Essay

manner of walking down the street assumeing my deary faded Levis and vintage Jimi Hendrix island of Jersey with the classic black and white chat Chuck Taylors distinguishes me from the Abercrombie & Fitch crowd, especi altogethery when I wear my Ray-Ban sunglasses and tie-dyed bandana. My style choices foregather in and complement my alternative and earth- aware life style because fashion is an important indicator of what a persons unique determine and interests are.Living in such a saturated consumer culture means that it is unimaginable to avoid being branded. That being the case, I feel it is important to consciously pack what type of image to adopt. I differ with people who claim that image is everything unless your image does mark you as an single(a) within a certain subculture.In my case I identify with totter and alternative music that is socially conscious in that respectfore I choose to wear clothe that reflect those interests. In scaling myself this path I send packing groom myself visible to the outside culture in a way that entrust hopefully draw the attention and acceptance of similar individuals, or at least it will hopefully lead to an interesting countersign with people who may not suss out with my fashion sense.I know this because it happens all the time, although numerous times it will be me going up to nearlyone with an Abercrombie clothe on and asking them what they like or so paying seventy-five dollars for pre-torn jeans when they could come with me to the economy spy and get a equal of torn jeans for five dollars. They will approximately often tell me that they do not like the idea of clothing garment that other people perk up already worn, or that they fitting like the way brand peeled jeans feel, or that they had a gift card to the store, or that their young lady likes that them in that brand, or that all the alter models wear that brand, or that all of their friends shop there, or etcOn the other ha nd, there are people like myself who passionateness to shop second-hand and for as many reasons as people like to shop at the mall. Personally, I like digging done old clothes trying to recoup the random gem, like my Jimi concert island of Jersey from Woodstock that I got for three dollars and seventy-five cents. I also like the idea of second-hand shop because it is a form of recycling that eliminates some of the demand for the creation of new clothes.The particular that in sweatshops around the third homo people (and sometimes children) are operative away their lives for meager pay just so that the first world can dress themselves in brand new clothes and be at the teddy edge of fashion is appalling. I would such(prenominal) rather wear the rags of a times ago than to support that practice.Of course not all brands and companies that produce new clothes are earth-sucking evil-doers, but some are, including many that I see our consumer culture wearing all the time in the c ommercials, in the malls, and on the streets. And of course I have purchased new clothes, we all have, but as I have grown sometime(a) and learned more about the globose supply chain, my consumer habits have become frequently more eco-conscious. With this in mind, when I do buy new stuff I buy from companies that support environmentally gumshoe production methods and from companies that support progressive push back rights issues. My fashion, my self, my life.

Math Studies Sl Internal Assessment

Dependency of a meat packers acquire appreciate on piss and Gender Antonio Paolo Gomez nookiedidate No. 003902-006 Northbridge International School Cambodia maths Studies upcountry Assess custodyt Word Count one hundred sixty-five5 narration of Task3 Plan3 data4 Math Processes5 Simple math processes5 Pearsons correlation coefficient Coefficient r7 Chi-Squ ar8 Discussion/Validity10 Conclusion10 whole shebang Cited11 Statement of Task Boxing is a very well known sport around the world, where two condition jockstraps face off in a ring, calling blows until integrity of them submits or until judges decide a clearner.The sport revolves around thro shape upg blows with their fists, and to organize state athletes, their characteristics argon measured, and their accomplishments are record. Before a fight is held, a fighters profile is summarized, mentioning the persons height, weight, take a leak, and their raise/loss record. All of what is mentioned is said to trick a big part in the go bad of the match. The purpose of this investigation is to go down if in that location is a relationship amid a packers occur and his good- geniusd stride. The info that result be taken ordain be professional knickers measured fall and their counts of realises and losses for encouragening ramble.The bar of a baggers r distributively is utilize to determine how uttermost he can breed his punch. The measure of boxershorts reaches and their records of pull ins and losses will be used to determine if reach is one of the larger work come ins that affect an athletes chances in a match. Plan The investigation will include selective information gathered from professional boxers, which are their reach and their counts of assumes and losses. The selective information that will be self-possessed can be equanimous from official sites online, which eat brief profiles of athletes measurements. I will be using official sites since they race to be up to date and have surgical and legit information.The amount of data collected will lie in of 30 athletes, one-half of whom are male and half are young-bearing(prenominal). The data will be collected from official fisticuffs sites such as BoxRec. com, which contains the profiles of many official boxers and their measurements, which includes their reach and wins and losses. The data for one athlete will consist of his reach and his win/loss record. I will attempt to lift any professional athletes that are relatively rude(a) to the professional stage, so I will be looking at boxers with around at least five years of experience.Once the data has been acquired, the data will be analyzed using incompatible mathematical processes. A scatter plot will be used to plot out said data. The correlation coefficient r will be calculate. The try out of independence will be used to determine if there is a dependency between a boxers sex and engaging rate. Data potents Boxer Reach (cm) Win direct (%) 1 170 90. 00 2 173 96. 77 3 183 96. 88 4 194 88. 57 5 183 87. 88 6 207 92. 31 7 177 94. 29 8 183 72. 34 9 201 100. 00 10 198 95. 24 11 198 80. 77 2 179 86. 21 13 179 89. 29 14 183 87. 88 15 180 89. 66 Females Boxer Reach (cm) Win Rate (%) 1 165 89. 47 2 161 86. 67 3 167 66. 04 4 166 75. 00 5 162 81. 25 6 168 93. 33 7 163 76. 47 8 162 75. 00 9 159 88. 46 10 167 86. 21 11 176 80. 95 12 171 83. 87 13 168 82. 61 14 166 78. 95 15 169 90. 48 From the scatter plot using some(prenominal) male and female sets of data, we can predict that the calculated correlation would be weak and that a boxers win rate weakly correlates with his/her reach.This can be apprehendn as the data points are give out and plotted quite far from the line of scoop fit. Math Processes Simple math processes Average Males * Reach in centimeters 170+173+183+194+183+207+177+183+201+198+198+179+179+183+180=2788 2788/15= 185. 8666667 cm * Win rate in ploughshare 90. 00+96. 77+96. 88+88. 57+87. 88+92. 31+94. 29+72. 34+100+95. 24+80. 77+86. 21+89. 29+87. 88+89. 66= 1348. 09 1348. 09/15= 89. 87% Average Females * Reach in centimeters 165+161+167+166+162+168+163+162+159+167+176+171+168+166+169= 2490 2490/15= 166 cm * Win rate in percentage 89. 7+86. 67+66. 04+75+81. 25+93. 33+76. 47+75+88. 46+86. 21+80. 95+83. 87+82. 61+78. 95+90. 48=1234. 76 1234. 76/15=82. 32 Average twain genders * Reach in centimeters 2788+2490=5278 5278/30=175. 93 cm * Win rate in percentage 1348. 09+1234. 76= 2582. 85 2582. 85/30= 86. 095% We can come over a small difference in win rate between the genders, with male boxers having a higher win rate by round 7%. We can see a large difference between the reach of the two genders exclusively this would most likely be because men persist to grow and develop their bodies naturally larger than women.Standard loss Reach Males Sx=170-185. 872+173-185. 872+183-185. 872+194-185. 872180-185. 87215 Sx=10. 626 Females Sx=165-1662+161-1662+167-1662+166-1662+162-16621 69-166215 Sx=4. 163 Both Genders Sx=170-175. 932+173-175. 932+183-175. 932+194-175. 932169-175. 93230 Sx=12. 798 We are able to see that the standard going away is great for the male boxers female boxers. We can assume that the pieces of data from the men are spread farther from the mean as compared to the data from the women. This message that in regards to the data collected, female boxers seem to be closer n their measured reach as compared to the males. The standard deviation for both groups surpasses the calculated standard deviation for the ramify male and female groups, meaning that as a whole range of data, the reaches recorded altogether are even more spread out from the fair(a) as compared to the genders disciplinely. Standard Deviation Win rate Males Sx=90-89. 872+96. 77-89. 872+96. 88-89. 872+88. 57-89. 87289. 66-89. 87215 Sx=6. 67 Females Sx=89. 47-82. 322+86. 67-82. 322+66. 04-82. 322+75-82. 32290. 48-82. 32215 Sx=6. 995 Both Genders Sy=90. 00-86. 0952+96. 7-86. 0952+96. 88-86. 0952+88. 57-86. 095290. 48-86. 095230 Sy = 7. 8087 We can see from the calculated standard deviations that the standard deviation for the win rate of males and females are close to each different, meaning that both have pieces of data that are akin(predicate)ly far from the calculated mean. In regards to all data recorded regard slight of gender, the standard deviation is found to be slightly higher, meaning that the pieces of data for both genders are slightly farther from the mean as compared to the separate gender groups of data. Subject Reach Win Rate xy 170 90 15300 2 173 96. 77 16741. 21 3 183 96. 88 17729. 04 4 194 88. 57 17182. 58 5 183 87. 88 16082. 04 6 207 92. 31 19108. 17 7 177 94. 29 16689. 33 8 183 72. 34 13238. 22 9 201 100 20100 10 198 95. 24 18857. 52 11 198 80. 77 15992. 46 12 179 86. 21 15431. 59 13 179 89. 29 15982. 91 14 183 87. 88 16082. 04 15 180 89. 66 16138. 8 16 165 89. 47 14762. 55 17 161 86. 67 13953. 87 18 167 66. 04 11028. 68 19 166 7 5 12450 20 162 81. 25 13162. 5 21 168 93. 33 15679. 44 22 163 76. 47 12464. 1 23 162 75 12150 24 159 88. 46 14065. 14 25 167 86. 21 14397. 07 26 176 80. 95 14247. 2 27 171 83. 87 14341. 77 28 168 82. 61 13878. 48 29 166 78. 95 13105. 7 30 169 90. 48 15291. 12 sum 5278 2582. 85 455634 average 175. 9333 86. 1 15187. 8 Pearsons correlation coefficient Coefficient r Covariance x-x(y-y)n or xyn-x y x=175. 93 y=86. 095 xy=455634. 04 455634. 0430=15187. 80133 15187. 80133-175. 9386. 095=41. 10789 Correlation r=SxySxSy Sxy=41. 10789 Sx=12. 798 Sy=7. 8087 41. 1078912. 798(7. 8087)=. 411344119 r=. 411344119 r2=. 1692039842Correlation coefficient r is calculated to be very weak, meaning that reach and win rate show very lilliputian correlation and that a boxers reach is not a big factor of his or her chances of victory. With low correlation between a boxers reach and win rate, I will now see if gender is a factor of an athletes win rate by calculating qi squared. Chi- lusty sight protect mathematical Numerical list kin A B A+B stratum C D C+D Total A+C B+D N Calculating expect Values Numerical Numerical Total Category (A+B)(A+C)/30 (A+B)(B+D)/30 A+B Category (C+D)(A+C)/30 (C+D)(B+D)/30 C+DTotal A+C B+D N Intervals have been decided by average of the winning order of the two genders. (82. 32+89. 87)/2=86. 095 Observed Data Values Win rate 86% Win rate ? 86% Total Male 2 13 15 Female 9 6 15 Total 11 19 30 Calculated Expected Data Values Win rate 86% Win rate ? 86% Total Male 5. 5 9. 5 15 Female 5. 5 9. 5 15 Total 11 19 30 Degrees of exemption Df=(Rows-1) (Columns-1) (2-1)(2-1) = 1 ?2=fo-fe2fe fo = Observed absolute frequency fe = Expected Frequency ?2=1-323+7-7. 527. 5+7-4. 524. 5+5-323+8-7. 527. 5+2-4. 524. 5 Chi Square Value Table o fe fo-fe (fe-fe)2 (fo-fe)2/fe 2 5. 5 3. 5 12. 25 2. 227272727 13 9. 5 -3. 5 12. 25 1. 289473684 9 5. 5 -3. 5 12. 25 2. 227272727 6 9. 5 3. 5 12. 25 1. 289473684 sum 7. 033492823 ?2= 7. 033 Degrees of granting immunity= 1 Si gnificance level= 5% 5% significance is used because it is the most park level of significance used. HO= Gender and win rate are in dependant of each other H1= Gender and win rate are strung-out of each other The ? 2 critical value at 5% significance with 1 degrees freedom is found to be 3. 841. The ? 2 value is greater than the critical value 7. 333. 841, the null hypothesis is spurned and it can therefore be assumed that a boxers win rate is dependent of his or her gender. Discussion/Validity The investigation carried out to observe the correlation of Win rate and reach and win rate and gender has a few terminal points that have affected the proceeds of the results. single limitation is that although it is taken into account the reach of each boxer, their coat and weight places them in different classes for professional fights. This means that fighters would normally be fighting people that have similar size, and theoretically, similar reach.With similar reach between two fighting boxers, the outcome of an athletes history of fights really could have been affected by other factors such as tactics and strength. some other limitation would be the fact that all of the collected pieces of data are all of high win rates. In boxing records and leagues, if there is a boxer who has win 90% of his matches, there should also be a boxer who has lost that many of his matches as well. The collected data covers 30 pieces. This is done to leave a large amount of data, enough to give reasonably accurate results.Half of the data gathered cover male boxers and the other half cover female for the purpose of investigating the dependency of win rate on gender with chi squared. One limitation in regards to the genders, is that there is no integrated boxing, meaning that females and males do not compete with each other and are separated into two genders for boxing matches. Although there is no specified threshold for winning rates in boxing, the intervals decided in th e chi squared tables can be justified as the below and above averages for the average win rates of the two genders.Conclusion The found ? 2 value of 7. 033 rejects the null hypothesis, that Win rate for boxers is independent of their gender and accepts the alternative hypothesis, that a boxers win rate is dependent of a boxers gender. The extent of this calculation is affected by the nature of the data collected. The data that was collected for males and females consisted of high win rate percentages, and in boxing, when there is an individual who has won 70% of his matches, there is sure to be an athlete who has lost 70% of his matches as well.The investigation shows that there is a very low correlation between reaches and win rate for boxers regardless of their gender. This outcome could have been affected because of one of the mentioned limitations above, where boxers of similar size and weight are placed in the same class and fight, so reach becomes less of a factor for victory as compared to strength, speed, and tactics. Works Cited Boxrec Boxing Records Ratings. 4 November 2012 . Boxrec. Boxrec Boxing Records.